Healthy Bodyweight Management Formulation

 


Obesity and overweight is a phenomenon due to unbalanced absorption and consumption of calories. The profound changes in modern dietary behavioral patterns result in the excess accumulation of calories and cause overweight and obesity problems. While genes are important in determining a person's susceptibility to weight gain, energy balance is determined by calorie intake and physical activity. Thus societal changes and worldwide nutrition transition are driving the obesity epidemic. Economic growth, modernization, urbanization and globalization of food markets are just some of the forces thought to underlie the epidemic.

As average incomes rise and populations migrate to urban area, diets enriched in complex carbohydrates give way to more diversed cuisines with a higher proportion of fats, especially saturated fats, and sugars. The tendency towards less physically demanding work, the increasing use of automatic transportation, as well as the prevalence of high-technology entertainment products, all lead to less active and unhealthy life styles.

According to World Health Organization (WHO), obesity and overweight are major risk factors for a number of chronic diseases, including：

 
  • Cardiovascular diseases (mainly heart diseases and stroke): the world's number one cause of death, with 17 million deaths each year.
  • Diabetes: a global epidemic disease. WHO projects that diabetic deaths will increase by more than 50% worldwide in the next 10 years.
  • Muscular and joints diseases: especially osteoarthritis.
  • Some cancers: such as endometrial, breast, and colon/rectum cancers.

Obesity impacts on not only physiological health but also psychological health and quality of life. Scientific researches have proved that maintaining ideal body weight help to improve the quality of life and psychological health (see Obesity reviews, Eating and Weight Disorders, International Journal of Obesity).

There are six major types of mechanisms for weight loss treatments in the market:

 
（1）Metabolic Blocker
Glucose absorption inhibitor: avoid fat accumulations. For example, HCA from the Garcinia cambogia extract is an analog of citric acid and is able to compete with the activity of ATP-Citrate lyase(ACL) so that interrupts the process of converting excess glucose to fat. HCA is a mild weight-loss component, and users may regain body weight easily.
Fat absorption inhibitor: avoid newly synthesized fat accumulations. For example, Xenical® weight loss medication acts mainly by inhibiting the fat-digesting enzymes. Xenical® inhibits the action of lipases in the gastrointestinal tract and prevents fat decomposition. The undigested fat particles are too big to be absort by the human body, and hence reduces about 30% of the fat absorption. However, long-term use will cause undesired effects, including decreased absorption of fat-soluble vitamins (such as vitamin A, D, E, and K), pathological changes in eye or skin, calcium absorption or blood coagulation deficits, and aging of the skin…etc.
 
 
（2）Metabolic Inducers  
Increase the glucose metabolism: avoid newly synthesized fat accumulations; promote glucose metabolism factors to accelerate the glucose metabolic pathways. For example, the vitamin B functions this way.
Increase the fat metabolism: metabolize the accumulated fat; promote fat metabolism factors to accelerate the fat metabolic pathway. Unsaturated fatty acids such as docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and evening primrose oil (EPO), are able to promote fat metabolism.
 
（3）Neurotransmitter Inhibitors  
Prolong the reaction time of norepinephrine and serotonin in the brain to increase the metabolic rate and promote fat consumption in cells. However, the undesired side effects include insomnia caused by an over-stimulated central nervous system (CNS), nausea, constipation or palpitations. An example for this kind of mechanism is Reductil® weight loss medication, and users may regain body weight easily when stop medication.
Phenylpropanolamine (PPA) is a major medication for cold. The characteristic for this treatment is sympathetic nerve stimulation and inhibition of the feeding center in hypothalamus to decrease the appetite. The mechanism is similar to ephedrine and amphetamine, but it is not addictive. Mild undesirable side effects include dry mouth, palpitations, insomnia, vision and conscious disturbances; severe effects are suspected to be related to brain hemorrhages and stroke.
 
 
（4）Dehydrants and waste digesters
Laxatives are the main items in this category. Common medications include magnesium oxide and sennosides. They mainly act in the gastrointestinal tract, causing intermittent diarrhea in this way, and the water and waste contents inside the body will be removed. Undesired side effects will be caused by the condition of long-term diarrhea, which affects nutrition absorption activity leading to anemia and malnutrition. If users are over-dependent on the medication, it will result in constipation and intestinal dysfunction; in more severe cases, dehydration, an imbalance between water and electrolytes, and fainting may happen.

（5）Appetite controllers
Meal replacements contain multiple nutrients; however, if an individual has three meal replacements each day, the calorie intake may be insufficient. Since the standard calorie intake for a dieting person should be 1000-1200 Kcal, people with three meal replaced per day will easily give up on dieting and resume their normal diet again with recurrent obesity problems. The meal replacements are convenient due to the fairly balanced nutritional content. It is suggested that dieters take 1-2 meal replacements each day, so the low-calorie characteristic of the meal replacement can be combined with a normal balanced meal, which will be gradually reduced day by day. However, the bad taste of some meal replacements taste bad does not satisfy the human desire to eat good-tasting food and may cause additional intake for mental needs.
High fiber diet, such as whole wheat or grains containing abundant fibers, will absorb water and swell in the stomach without being comsumed and digested, and will make people feel satiated and decrease the appetite. However, fibrous foods are nonfat with an unattractive taste, so people are always reluctant to eat continuously, but instead increase the amount of their other food intake, leading to obesity.
High protein diet contains mainly food with protein source and excludes glucose and fat intakes; the unbalanced nutritional intake will lead to abnormal physiological and metabolic activity.
 
（6）Metabolic integrators  
Integrated weight loss medication is an all-purpose and most complete formulation. Through the promoted biochemical metabolism and inhibition on the integrated regulation, weight loss will be achieved. The complex mechanisms are as follows: inhibiting the new fat formation converted from excessive glucose; promoting glucose metabolism to avoid new fat accumulation; inhibiting excessive fats accumulation; accelerating the metabolism of the accumulated fats and then transforming into energy source. The metabolic integration bases on safety and balance to regulate the body metabolism so the weight loss mechanism will not be a one-way or a biased complete disruption or acceleration. The biochemical metabolic regulation will be adjusted according to the status of your body.
 
 

Introduction to MT4
  MT4 is an all-round integrated weight formulation developed based on the princile of the WHO’s health proposal and Japan’s most popular “health weight management” concept. Unlike most ordinary weight management products on the market, MT4 relies on integrated control of the body’s biochemical metabolism to achieve weight loss. Its metabolic integration stresses safety and balance; it regulates the body’s metabolism and doesn’t rely on one-way,or partial blocking/promoting to achieve weight loss.
Characteristics
 
  1. Regulates the body’s metabolism and doesn’t rely on one-way or partial blocking/promoting to achieve weight loss.
  2. Pure natural botanical essence without any side effects.
  3. Promotes the health and does benefits to weight losing of the users at the same time.
  4. Adding the most novel health weight controlling ingredients with a better health and weight losing effect.